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c/tirzepatide·submitted 1 year ago by u/tidy_vialdrawer_pls

[Question] GIP — what am I missing here

Questionbranch of 13 comments

Week 52 update. 13kg down from the start, muscle cramps basically gone since about week 9. Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with muscle cramps. The part that surprised me is how much of this is admin.…

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13 comments, started 1 year ago
u/tidy_vialdrawer_pls819 points·1 year ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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[deleted]588 points·1 year ago

[deleted]

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u/throwaway_wl2026154 points·1 year ago

week 9 on Mounjaro and the appetite profile is genuinely different from sema

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u/mod_cold_roommod · c/coldchain-3 points·1 year ago

the dual agonism hits different and that is why people describe it differently

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u/curious_panel_only252 points·1 year ago·edited

the appetite change on tirz is more than just reduced hunger, it is different machinery

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/neha_falk194 points·1 year ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/ahmed_iyer43 points·1 year ago

SURMOUNT data is messier than STEP data but the weight loss is there

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/ewan_marchand30 points·1 year ago

Respectfully this is a sample of one presented as a finding.

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u/b12_baseline10 points·1 year ago

the GIP side does different things than the GLP-1 side, that is the point

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u/samir_falk165 points·1 year ago

do not crack the pen, we have been over this

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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