SURPASS — 5 things I got wrong before I got it right
Confession thread, sort of.
I went from 7.5mg to 2.4mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 12 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.
So now I have injection-site soreness I did not need and a data point I cannot interpret. Two lessons in one.
Posting it in the hope that somebody at week 36 reads it before doing the same thing.
best — the order this archive was captured in
week 40 on Mounjaro and the appetite profile is genuinely different from sema
week 40 on Mounjaro and the appetite profile is genuinely different from sema
Yes, exactly this, and it is the bit that took me 27 weeks to accept.
the GIP side does different things than the GLP-1 side, that is the point
This is the "correlation is mechanism" thing again. You changed three variables at once.
the 15mg is the top of the pen, not the required dose
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
Hard agree. The food noise disappears differently on the two compounds.
week 67 on Mounjaro and the appetite profile is genuinely different from sema
Slight fix: the number was 98.7, not 98.6. Decimal point, but a fairly consequential one.
My ALT moved faster on tirz than on sema at the same timepoint, which matches what people report.
the reflux from tirz is different, not necessarily worse
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The SURMOUNT readouts are real but less consistent than STEP. Some people plateau earlier on tirz.
What was the trial arm you are quoting from? SURMOUNT-1, -2, -3 are all different.
dual agonism is GIP, do not generalise from semaglutide
Is that on Mounjaro pens or research tirzepatide?
Tried both. Sema worked, tirz worked better for me, but my reflux profile was worse on tirz.
do not crack the pen, we have been over this
- 1week 67 on Mounjaro and the appetite profile is genuinely different from sema6 comments in this branch · started by u/marit_sandvik
- 2What was the trial arm you are quoting from? SURMOUNT-1, -2, -3 are all…5 comments in this branch · started by u/forest_plot_fiona