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c/tirzepatide·submitted 8 months ago by u/ghrp_history

SURPASS — 5 things I got wrong before I got it right

Titrationbranch of 5 comments

Confession thread, sort of. I went from 7.5mg to 2.4mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 12 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have…

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5 comments, started 7 months ago
u/forest_plot_fionastats41 points·7 months ago

What was the trial arm you are quoting from? SURMOUNT-1, -2, -3 are all different.

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u/incretin_ivypharmacology17 points·7 months ago

dual agonism is GIP, do not generalise from semaglutide

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u/ignacio_vanhecke9 points·7 months ago

Is that on Mounjaro pens or research tirzepatide?

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u/ghrp_historyOP7 points·7 months ago

Tried both. Sema worked, tirz worked better for me, but my reflux profile was worse on tirz.

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u/santiago_villalobos11 points·7 months ago

do not crack the pen, we have been over this

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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