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c/tirzepatide·submitted 6 months ago by u/customs_seizure_sid

[Meta] proposal — a flair for SURMOUNT posts

Titrationbranch of 7 comments

Trying to settle this properly because the thread from last year went in circles. The claim: tirzepatide matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 13 months without either producing anything. What would actually settle it is 29 people measuring the…

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7 comments, started 6 months ago
u/laila_yilmaz31 points·6 months ago

This matches the trial data. SURMOUNT-1 was 98.3% body weight at 13 weeks.

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u/kian_ekstrom21 points·6 months ago

the dual agonism hits different and that is why people describe it differently

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[removed]16 points·6 months ago

[removed by moderator]

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u/georgi_chowdhury4 points·6 months ago

[removed by moderator]

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/kofi_balogun13 points·6 months ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/throwaway_titration8 points·6 months ago

Slight fix: the number was 96.8, not 98.1. Decimal point, but a fairly consequential one.

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u/b12_baseline17 points·6 months ago

Not to be pedantic but dual agonist and 15mg are being used interchangeably and they are not interchangeable in real life.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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