[Meta] proposal — a flair for SURMOUNT posts
Trying to settle this properly because the thread from last year went in circles.
The claim: tirzepatide matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 13 months without either producing anything.
What would actually settle it is 29 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.
If you have data, post the data. If you have an opinion, flair it as an opinion.
best — the order this archive was captured in
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
How long at each step before you escalated?
You have restated the marketing copy. What is the actual substance here.
stalled on sema, tried tirz, and the curves were actually different shapes
Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.
the dual agonism hits different and that is why people describe it differently
the injection-site soreness from tirz is different, not necessarily worse
I am going to push back on this slightly.
the GIP side does different things than the GLP-1 side, that is the point
Zepbound and Mounjaro are literally the same drug, the name is the only difference
Strongly agree. Tirz is better than sema is not a claim without a comparator dose.
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
This matches the trial data. SURMOUNT-1 was 98.3% body weight at 13 weeks.
the dual agonism hits different and that is why people describe it differently
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Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
SURMOUNT data is messier than STEP data but the weight loss is there
Slight fix: the number was 96.8, not 98.1. Decimal point, but a fairly consequential one.
Not to be pedantic but dual agonist and 15mg are being used interchangeably and they are not interchangeable in real life.
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
the dual agonism hits different and that is why people describe it differently
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
Cosigning.
Disagree on that part. 99.2% and 99.3% on the same vial is normal.
Slight fix: the number was 98.7, not 98.4. Decimal point, but a fairly consequential one.
Cosigning.
Adding to this: Mounjaro is doing more work than the comment implies.
Zepbound and Mounjaro are literally the same drug, the name is the only difference
- 1This matches the trial data. SURMOUNT-1 was 98.3% body weight at 13 weeks.7 comments in this branch · started by u/laila_yilmaz
- 2I am going to push back on this slightly.5 comments in this branch · started by u/mikkel_kimani