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c/tirzepatide·submitted 11 months ago by u/ignacio_vanhecke

[Question] how do you actually verify SURPASS

Questionbranch of 8 comments

Confession thread, sort of. I went from 2.4mg to 0.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 20 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have muscle…

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8 comments, started 11 months ago
u/zeynep_ndiaye281 points·11 months ago

Strongly agree. Tirz is better than sema is not a claim without a comparator dose.

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u/titration_marshalmod · c/semaglutide70 points·11 months ago

Strongly agree.

Adding to this: SURPASS is doing more work than the comment implies.

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u/taper_off_tabitha120 points·11 months ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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[deleted]52 points·11 months ago

[deleted]

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u/vito_chowdhury235 points·11 months ago

the dual agonism hits different and that is why people describe it differently

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u/kofi_balogun188 points·11 months ago

Not convinced. The evidence does not support that reading.

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u/ignacio_vanheckeOP74 points·11 months ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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u/copay_card_cc24 points·11 months ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

Disagree on that part. 97.4% and 99.3% on the same vial is normal.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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