Germany: SURMOUNT, and what it actually costs here
Right, the Mounjaro question again, but with numbers this time. I have 4 data points over 24 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am…
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
the GIP side does different things than the GLP-1 side, that is the point
The SURMOUNT readouts are real but less consistent than STEP. Some people plateau earlier on tirz.
The SURMOUNT readouts are real but less consistent than STEP.
Disagree on that part. 99.0% and 98.9% on the same vial is normal.
Small correction: the trial was 13 weeks, not 11. Does not change your point but people will quote it.
The confident tone is doing a lot of work that the evidence is not.
the early fullness from tirz is different, not necessarily worse
the GIP side does different things than the GLP-1 side, that is the point
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
Yes, exactly this, and it is the bit that took me 76 weeks to accept.
That is net peptide content, not purity. Different number, different meaning.
the appetite change on tirz is more than just reduced hunger, it is different machinery
the dual agonism hits different and that is why people describe it differently