Germany: SURMOUNT, and what it actually costs here
Right, the Mounjaro question again, but with numbers this time.
I have 4 data points over 24 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.
The thing I would flag for anyone new: the effect I am describing showed up at week 59, not week 13. People give up long before the interesting part.
Interested in whether this matches other people's logs or whether I am an outlier.
best — the order this archive was captured in
stalled on sema, tried tirz, and the curves were actually different shapes
The confident tone is doing a lot of work that the evidence is not.
the dual agonism hits different and that is why people describe it differently
Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.
That is net peptide content, not purity. Different number, different meaning.
the 15mg is the top of the pen, not the required dose
How long at each step before you escalated?
Disagree but this is the good kind of wrong — it is specific enough to be checked.
Zepbound and Mounjaro are literally the same drug, the name is the only difference
the early fullness from tirz is different, not necessarily worse
SURMOUNT data is messier than STEP data but the weight loss is there
do not crack the pen, we have been over this
Strongly agree. Tirz is better than sema is not a claim without a comparator dose.
the dual agonism hits different and that is why people describe it differently
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
the GIP side does different things than the GLP-1 side, that is the point
The SURMOUNT readouts are real but less consistent than STEP. Some people plateau earlier on tirz.
The SURMOUNT readouts are real but less consistent than STEP.
Disagree on that part. 99.0% and 98.9% on the same vial is normal.
Small correction: the trial was 13 weeks, not 11. Does not change your point but people will quote it.
The confident tone is doing a lot of work that the evidence is not.
the early fullness from tirz is different, not necessarily worse
the GIP side does different things than the GLP-1 side, that is the point
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
Yes, exactly this, and it is the bit that took me 76 weeks to accept.
That is net peptide content, not purity. Different number, different meaning.
the appetite change on tirz is more than just reduced hunger, it is different machinery
the dual agonism hits different and that is why people describe it differently
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
Week 31 on Mounjaro and 15kg down. The appetite reduction feels different from sema in ways I do not have words for yet.
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
Crossposting this to c/semaglutide because the people who need it are not reading this community.
- 1Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.12 comments in this branch · started by u/amara_halonen
- 2Water content matters more than people think. If a vial is carrying residual…10 comments in this branch · started by u/tove_vasquez