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Single comment threadYou are looking at one branch of week 96 check-in — 11kg down, the food-noise thing manageable, one thing confusing me — 46 comments in the full submission. View in context.
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c/tirzepatide·submitted 1 year ago by u/emil_okwuosa

week 96 check-in — 11kg down, the food-noise thing manageable, one thing confusing me

Resultsbranch of 7 comments

Right, the SURPASS question again, but with numbers this time. I have 16 data points over 34 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am…

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7 comments, started 1 year ago
u/mod_cold_roommod · c/coldchain37 points·1 year ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/tidy_vialdrawer_pls19 points·1 year ago

the 15mg is the top of the pen, not the required dose

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u/kian_ekstrom13 points·1 year ago

Did you stay on semaglutide or switch? The outcome is different if you are comparing.

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u/hub_opssite staff11 points·1 year ago

the early fullness from tirz is different, not necessarily worse

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u/throwaway_titration3 points·1 year ago

Did you stay on semaglutide or switch?

Disagree on that part. 96.8% and 96.2% on the same vial is normal.

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u/discount_math_dm10 points·1 year ago

Mechanistically the bit that matters is Mounjaro. It explains most of the early profile and a decent chunk of the outcome.

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u/endpoint_creep3 points·1 year ago

Mechanistically the bit that matters is Mounjaro.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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