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c/trialwatch·submitted 1 year ago by u/rulebook_rachael

what would you tell week-1 you about hazard ratio

Paperbranch of 8 comments

Right, the TRIUMPH question again, but with numbers this time. I have 6 data points over 34 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am describing…

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8 comments, started 1 year ago
u/rohan_cardoso170 points·1 year ago

Titration speed is a side-effect dial far more than an efficacy dial.

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u/joaquin_stanescu44 points·1 year ago

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

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u/hugo_norgaard11 points·1 year ago

absolute risk reduction, not relative risk reduction, that is how you decide

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u/marit_laurent14 points·1 year ago·edited

number-needed-to-treat is the house dialect

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u/nightowl_injector21 points·1 year ago

Disagree. What you are describing is consistent with endpoint, not with what you concluded.

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u/injection_site_iris12 points·1 year ago

Strongly agree. Phase 2 is investigational, not conclusive.

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u/slow_logbook_notes30142 points·1 year ago

Yeah, absolute numbers matter more than the press release.

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u/rt_shift_reggie108 points·1 year ago

the discontinuation arms are the interesting part, not the STEP endpoints

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