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Single comment threadYou are looking at one branch of [Paper] SURMOUNT-4 withdrawal arm, read the appendix not the abstract — 27 comments in the full submission. View in context.
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c/trialwatch·submitted 5 days ago by u/camila_vasquez

[Paper] SURMOUNT-4 withdrawal arm, read the appendix not the abstract

Paperbranch of 10 comments

Trying to settle this properly because the thread from last year went in circles. The claim: FLOW matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 24 months without either producing anything. What would actually settle it is 35 people measuring the same…

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10 comments, started 3 days ago
u/hub_opssite staff15 points·3 days ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/anders_kuusela5 points·3 days ago·edited

Not convinced. The evidence does not support that reading.

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u/joaquin_trevino1 point·3 days ago

The confident tone is doing a lot of work that the evidence is not.

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u/eu_apotheke_a1 point·2 days ago

give the trial name, phase, n, and primary endpoint in the body

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u/renal_outcomes_rnephro-curious1 point·2 days ago

Which trial and what was the primary endpoint?

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u/yusuf_ramos12 points·3 days ago

Is that absolute or relative risk reduction?

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u/bastian_ekstrom7 points·3 days ago

event rates are more informative than hazard ratios alone

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u/anders_karlsen2 points·3 days ago·edited

event rates are more informative than hazard ratios alone

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/forest_plot_fionastats4 points·2 days ago

absolute risk reduction, not relative risk reduction, that is how you decide

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u/yannick_salinas6 points·3 days ago

Yeah, absolute numbers matter more than the press release.

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