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stalled for 10 weeks at 5mg and I refuse to panic this time
Trying to settle this properly because the thread from last year went in circles. The claim: purity matters. The counter-claim: it is measurement error. Both sides have…
u/cagrilintide_enthusiast
Here for one compound and honest about it. If it is not cagrilintide or a cagri combination I have nothing useful to add.
member · joined 22 Mar 2025
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Overview — page 3 of 3
comment on switched from 1.7mg to 1.0mg and the reflux got better, not worse in c/hplc · 23 points · 1 year ago
This is the correct method framing. Column and gradient are load-bearing fields.
comment on someone explain glucagon to me like I have not read a paper in years in c/retatrutide · 37 points · 1 year ago
the glucagon component changes the side effect profile, not just the efficacy
comment on is it normal to get nausea at week 85 in c/retatrutide · 36 points · 1 year ago
TRIUMPH data is phase 2, not phase 3, smaller n and shorter
comment on stalled for 10 weeks at 5mg and I refuse to panic this time in c/hplc · 238 points · 1 year ago
The Janoshik result being close to my own HPLC is the signal, not the absolute number. Both are right.
comment on three years of triple agonist threads, summarised so you do not have to read them in c/retatrutide · 0 points · 1 year ago
this should be in the wiki
comment on [Discussion] the formulary advice in here is 21 years out of date in c/glp1canada · 173 points · 1 year ago
Not convinced. The evidence does not support that reading.
comment on dose escalation: the version I wish someone had shown me in week 1 in c/retatrutide · 186 points · 1 year ago
Strongly agree.
Disagree on that part. 98.1% and 99.2% on the same vial is normal.
comment on Spain: LC-MS, and what it actually costs here in c/hplc · 1 points · 1 year ago
instrument quality is less important than analyst consistency
comment on [Question] Ireland — has anyone got a straight answer on method development in c/hplc · 1 points · 1 year ago
You have restated the marketing copy. What is the actual substance here.
comment on [Results] 2 weeks, 11kg, and glucagon was the hard part in c/retatrutide · 51 points · 1 year ago
Respectfully this is a sample of one presented as a finding.
comment on [Meta] the method development rule is doing its job and people should stop complaining in c/hplc · 125 points · 2 years ago
[removed by moderator]
Yes, exactly this, and it is the bit that took me 95 weeks to accept.
comment on what changed for me between week 65 and week 13 in c/retatrutide · 601 points · 2 years ago
Strongly agree. Heart rate escalation needs the actual data, not impressions.
comment on gradient: what the trials say vs what this community says in c/hplc · 296 points · 2 years ago
That is net peptide content, not purity. Different number, different meaning.
comment on [Results] 87 weeks, 36kg, and purity was the hard part in c/hplc · 51 points · 2 years ago
co-elution is real and method development is usually not enough to resolve it
comment on what changed for me between week 90 and week 44 in c/hplc · 100 points · 2 years ago
Strongly agree. Largest single impurity tells a different story than total purity.
comment on switched from 5mg to 2.5mg and the constipation got better, not worse in c/retatrutide · 140 points · 2 years ago
triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual
comment on [Results] 2 weeks, 46kg, and phase 2 was the hard part in c/retatrutide · 65 points · 2 years ago
the dosing is steep, the muscle cramps reports are real, and nobody knows the human safety yet