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c/retatrutide·posted 2 years ago by u/andres_sorensen

switched from 5mg to 2.5mg and the constipation got better, not worse

Trial Data Long Haul ×8 Cold Box ×3 Well Actually ×1

I have had 24 orders now and I keep a table, so here is the honest summary rather than a vibe.

Material has been consistent. Communication has not. Shipping has varied by about 10 days on nominally the same lane, which matters more in summer than in February.

The independent number came back 98.4% against a claimed 98.6%, which I read as agreement rather than a discrepancy — inter-lab variance on this assay is a point or two either way and treating one lab as ground truth is how people end up in pointless arguments with vendors.

Batch number is in the comments. Ask if you want the method.

9,484 up / 2,117 down82% upvoted30 commentsid 1bls2q6 Oct 2023

30 comments

25 in this archive, depth 5

best — the order this archive was captured in

u/ledger_modMOD707 points·2 years ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/nikhil_asante573 points·2 years ago·edited

phase 2 numbers are not maintenance numbers, cite the trial

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u/hugo_pires493 points·2 years ago

This is correct. Triple agonism is genuinely different.

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u/ferran_krastev174 points·2 years ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/nikhil_asante-19 points·2 years ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/yara_lindholm1 point·2 years ago

Did you actually measure heart rate or is that a feeling?

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u/nikhil_asante1 point·2 years ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/nikhil_lindqvist1 point·2 years ago

the glucagon component changes the side effect profile, not just the efficacy

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u/ferran_krastev1 point·2 years ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/devils_advocate_d376 points·2 years ago

Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.

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u/nikhil_lindqvist460 points·2 years ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/anya_moreau224 points·2 years ago

This is correct. Triple agonism is genuinely different.

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u/employer_carveout276 points·2 years ago

the weight curves are unusually steep, which makes predicting individual response harder

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u/careful_gradient_again192 points·2 years ago

Did you actually measure heart rate or is that a feeling?

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u/employer_carveout46 points·2 years ago

phase 2 numbers are not maintenance numbers, cite the trial

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u/ledger_modmod · vetting313 points·2 years ago

the weight curves are unusually steep, which makes predicting individual response harder

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/farid_molnar77 points·2 years ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

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u/nordic_pricing60 points·2 years ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

Adding to this: TRIUMPH is doing more work than the comment implies.

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u/cold_chromatogram_only48 points·2 years ago·edited

research use only, handling and analysis, not protocols

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u/yannick_barros46 points·2 years ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/reta_and_regret240 points·2 years ago

the weight curves are unusually steep, which makes predicting individual response harder Counter-anecdote: opposite result, same dose.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/vito_beaulieu174 points·2 years ago

the glucagon component changes the side effect profile, not just the efficacy

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u/ismael_eriksen45 points·2 years ago

the dosing is steep, the sulphur burps reports are real, and nobody knows the human safety yet

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u/nikhil_lindqvist124 points·2 years ago

The confident tone is doing a lot of work that the evidence is not.

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u/cagrilintide_enthusiast140 points·2 years ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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c/retatrutide rules
  1. Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
  2. Phase 2 numbers are not maintenance numbers. Cite the trial and the dose arm.
  3. Heart-rate and dose-escalation reports need actual measurements, not impressions.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
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Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.