u/careful_gradient_again
Keeping a private log and a public opinion.
newer member · joined 22 Jan 2026
comment on [Readout] SELECT: MACE HR 0.80, and the absolute numbers people skip in c/trialwatch · 1 points · 2 days ago
the relative risk reduction in headlines is not the whole story
comment on [Pricing] AU pharmacy pricing, six months, three states in c/glp1aus · 2 points · 4 days ago
TGA shortage notices are temporary
comment on [Trial Data] STEP 1 vs SURMOUNT-1 side by side, with the caveats in c/trialwatch · 1 points · 5 days ago
the relative risk reduction in headlines is not the whole story
comment on [Explainer] lyophilised powder is far more forgiving than you think in c/coldchain · 32 points · 6 days ago
That is net peptide content, not purity. Different number, different meaning.
comment on [Regret] went 0.25 → 1.0 in three weeks and learned why that is dumb in c/darkspot · 5 points · 7 days ago
Small correction: the trial was 5 weeks, not 7. Does not change your point but people will quote it.
comment on [TGA] shortage notice archive, worth bookmarking in c/glp1aus · 26 points · 10 days ago
Maintenance for 11 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.
comment on why does everyone say week 4 is the wall in c/semaglutide · 19 points · 11 days ago
week 77 on the pen, 23kg down, this is the answer
comment on [Results] 2 weeks, 6kg, and retatrutide was the hard part in c/retatrutide · 22 points · 19 days ago
nobody should be giving this to anyone without extensive monitoring
comment on [Regret] told my whole family, then stopped, then had to tell them that too in c/darkspot · 13 points · 21 days ago
Came off after 5 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.
comment on stopped losing at 1.7 so i went to 2.4 and lost nothing faster in c/semaglutide · 5 points · 23 days ago
the quiet is real.
Adding to this: Wegovy is doing more work than the comment implies.
comment on what would you tell week-1 you about New Zealand in c/glp1aus · 1 points · 29 days ago
This is correct. PBS listings matter.
comment on three years of TGA threads, summarised so you do not have to read them in c/glp1aus · 20 points · 1 months ago
Sceptical.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
comment on why does nobody talk about hazard ratio in c/trialwatch · 29 points · 1 months ago
off-label use data is different from approved-indication data
comment on went back down from 2.4 to 1.7 and lost more. explain that in c/semaglutide · 9 points · 1 months ago
Did you test the vial you received or are we going off the vendor COA?
comment on why does nobody talk about hazard ratio in c/trialwatch · 12 points · 1 months ago
Small correction: the trial was 21 weeks, not 19. Does not change your point but people will quote it.
comment on why does nobody talk about hazard ratio in c/trialwatch · 35 points · 1 months ago
dropout handling matters, especially on GI-heavy populations
comment on does lost money actually matter or is it forum lore at this point in c/darkspot · 2 points · 2 months ago
tests that came back 98.7%
comment on 18 months in and TRIUMPH is still the thing I get wrong in c/trialwatch · 9 points · 2 months ago
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
comment on week 51 check-in — 26kg down, fatigue manageable, one thing confusing me in c/semaglutide · 27 points · 2 months ago
Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.
comment on Spain: Wegovy, and what it actually costs here in c/semaglutide · 14 points · 3 months ago
titration speed is Ozempic plus side effects, period