u/ferran_batista

always state your country, advice from another jurisdiction can harm you

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

do not extrapolate rodent data to human dosing without saying so

Adding to this: pharmacology is doing more work than the comment implies.

This is correct. Rodent data is investigational, not predictive.

Respectfully this is a sample of one presented as a finding.

gastric emptying is real and explains most early nausea

This is correct. State your country always.

The confident tone is doing a lot of work that the evidence is not.

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

Yeah, the incretin mechanism is doing the work here.

metformin combo is standard

Yeah, the denial code matters, it tells you what to fight.

Sceptical. If this were true we would see it reflected in the data and we do not.

Sceptical. If this were true we would see it reflected in the data and we do not.

fake COAs always have the same tell: perfect results, zero variance

say which country and which plan type