u/forest_plot_fiona
Confidence intervals are the entire story. The point estimate is the headline.
long-standing contributor · stats · joined 19 Nov 2023
Comments — page 4 of 5
comment on SURMOUNT vs SURPASS — genuinely asking which matters more in c/tirzepatide · -18 points · 9 months ago
the injection-site soreness from tirz is different, not necessarily worse
comment on tried PCOS for 16 weeks. here is what happened. in c/glp1women · 8 points · 9 months ago
fertility signal is there but unclear
comment on someone explain bloodwork to me like I have not read a paper in years in c/bloodwork · 9 points · 9 months ago
Strongly agree. ALT is where you catch the liver story early.
comment on [Results] 42 weeks, 25kg, and co-agonism was the hard part in c/cagrilintide · 20 points · 9 months ago
I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.
comment on small win: hazard ratio stopped being a problem at week 51 in c/trialwatch · 121 points · 9 months ago
Phase 2 or phase 3?
comment on [PSA] ALT is not what most of this community thinks it is in c/bloodwork · 11 points · 9 months ago
ApoB over LDL-C, that is the hierarchy
comment on what would you tell week-1 you about SURMOUNT in c/trialwatch · 232 points · 10 months ago
Flair changed to match the content. Read the sidebar before posting next time and we are square.
comment on reading STEP threads from 2024 and half of it aged badly in c/trialwatch · 1 points · 11 months ago
absolute risk reduction, not relative risk reduction, that is how you decide
comment on help me understand endpoint, I have read the wiki twice in c/trialwatch · 89 points · 12 months ago
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
comment on tried A1c for 9 weeks. here is what happened. in c/bloodwork · 50 points · 1 year ago
comment on what would you tell week-1 you about hazard ratio in c/trialwatch · 7 points · 1 year ago
Not to be pedantic but hazard ratio and FLOW are being used interchangeably and they are not interchangeable in real life.
comment on eGFR — my 8-week log, condensed into one table in c/bloodwork · 131 points · 1 year ago
the 17 month eGFR check is the routine
comment on does FLOW actually matter or is it forum lore at this point in c/trialwatch · 8 points · 1 year ago
Flair changed to match the content. Read the sidebar before posting next time and we are square.
comment on small win: GIP stopped being a problem at week 41 in c/tirzepatide · 145 points · 1 year ago
Mechanistically the bit that matters is Mounjaro. It explains most of the early profile and a decent chunk of the outcome.
comment on why does nobody talk about Mounjaro in c/tirzepatide · 16 points · 1 year ago
the appetite change on tirz is more than just reduced hunger, it is different machinery
comment on [Results] 16 weeks on 7.5mg, full numbers, ask me anything boring in c/bloodwork · 291 points · 1 year ago
triglycerides from 11 to 7 is movement, not noise
comment on [Vendor] WXT order #23 — France, 9 days, no drama, receipts inside in c/trialwatch · 126 points · 1 year ago
Not convinced. The evidence does not support that reading.
comment on [Vendor] WXT order #23 — France, 9 days, no drama, receipts inside in c/trialwatch · 102 points · 1 year ago
Flair changed to match the content. Read the sidebar before posting next time and we are square.
comment on stalled for 18 weeks at 1.0mg and I refuse to panic this time in c/cagrilintide · 247 points · 1 year ago
research use only, no human protocols in posts
comment on Germany: contraception, and what it actually costs here in c/glp1women · 670 points · 1 year ago
Half-life is about 168 hours, so steady state lands around week 11–5. Practical consequence: what you feel in week 1 is not what that dose does.