does FLOW actually matter or is it forum lore at this point
Trying to settle this properly because the thread from last year went in circles.
The claim: FLOW matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 22 months without either producing anything.
What would actually settle it is 3 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.
If you have data, post the data. If you have an opinion, flair it as an opinion.
best — the order this archive was captured in
off-label use data is different from approved-indication data
Which trial and what was the primary endpoint?
the discontinuation arms are the interesting part, not the SURPASS endpoints
I am going to push back on this slightly.
Respectfully this is a sample of one presented as a finding.
event rates are more informative than hazard ratios alone
Flair changed to match the content. Read the sidebar before posting next time and we are square.
event rates are more informative than hazard ratios alone
Slight fix: the number was 99.2, not 99.1. Decimal point, but a fairly consequential one.
Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.
genuine question, not being difficult: how do you know
Disagree on that part. 98.1% and 98.9% on the same vial is normal.
Strongly agree. Phase 2 is investigational, not conclusive.
the 11 week readout is different from the 5 week readout
give the trial name, phase, n, and primary endpoint in the body
genuine question, not being difficult: how do you know Disagree on that part.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
event rates are more informative than hazard ratios alone
the 18 week readout is different from the 19 week readout
I am going to push back on this slightly.
Not convinced. The evidence does not support that reading.
the relative risk reduction in headlines is not the whole story
dropout handling matters, especially on GI-heavy populations
- 1genuine question, not being difficult: how do you know13 comments in this branch · started by u/sofia_ferreira
- 2Respectfully this is a sample of one presented as a finding.6 comments in this branch · started by u/formulary_fighter