u/hsa_math

press release SURMOUNT posts must be flaired until a publication exists

The tier 3 pathway in my area: 16 month wait, then 4 months for review, then approved. Total MHRA.

oral non-peptide agonist is ACHIEVE, no food restrictions

My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

What was the dropout rate?

event rates are more informative than hazard ratios alone

Respectfully this is a sample of one presented as a finding.

Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.

say which nation, England, Scotland, Wales, NI differ

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

phase 2 is not phase 3, smaller n and shorter trial

phase 2 is not phase 3, smaller n and shorter trial

Boots stock is hit-and-miss by location

dropout handling matters, especially on GI-heavy populations

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

Yeah, absolute numbers matter more than the press release.

Strongly agree. Phase 2 is investigational, not conclusive.

event rates are more informative than hazard ratios alone