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u/nightowl_injector

Evening dosing sleeps through the worst of it. Anecdote, not advice.

member · joined 13 Mar 2025

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Overview — page 3 of 5

comment on Canada: endpoint, and what it actually costs here in c/trialwatch · 35 points · 3 months ago

Not to be pedantic but FLOW and SURMOUNT are being used interchangeably and they are not interchangeable in real life.

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comment on the packaging thing finally clicked for me and I want to write it down in c/coldchain · 19 points · 5 months ago

Do you have the logger trace?

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comment on [Meta] proposal — a flair for dose history posts in c/dosinglogs · 28 points · 5 months ago

The early fullness was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

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comment on why does nobody talk about what is in c/newbiequestions · 29 points · 5 months ago

You have restated the marketing copy. What is the actual substance here.

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comment on [Lab] 7th independent test on QSC, and the trend is the interesting part in c/coldchain · 157 points · 5 months ago

The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.

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comment on the excursion thing finally clicked for me and I want to write it down in c/coldchain · 23 points · 6 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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comment on [Discussion] can we stop arguing about lyophilised until somebody posts a number in c/coldchain · 1 points · 6 months ago

lane reports need origin, destination, carrier, and actual transit days

Yes, exactly this, and it is the bit that took me 67 weeks to accept.

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comment on switched from 0.25mg to 15mg and the nausea got better, not worse in c/dosinglogs · 4 points · 6 months ago

Yeah, the consistency is the value.

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comment on [Discussion] we are measuring waist at the wrong time and calling it noise in c/dosinglogs · -12 points · 7 months ago

public logs kept over 23 weeks and beyond

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comment on the normal thing finally clicked for me and I want to write it down in c/newbiequestions · 1 points · 9 months ago

Respectfully this is a sample of one presented as a finding.

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comment on FLOW vs TRIUMPH — genuinely asking which matters more in c/trialwatch · 12 points · 9 months ago

Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.

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comment on help me understand log, I have read the wiki twice in c/dosinglogs · 223 points · 9 months ago

Came off after 47 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

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comment on Canada: dose history, and what it actually costs here in c/dosinglogs · 15 points · 9 months ago

Stalled for 9 weeks, changed nothing, and it started moving again on week 48.

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comment on what is is the most under-discussed thing in c/glp1uk in c/newbiequestions · 28 points · 9 months ago

Week 23 or week 35?

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comment on week 6 check-in — 36kg down, sulphur burps manageable, one thing confusing me in c/dosinglogs · 31 points · 10 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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comment on reading stability threads from 2024 and half of it aged badly in c/coldchain · 37 points · 11 months ago

This is correct.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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comment on [Discussion] the log advice in here is 9 years out of date in c/dosinglogs · 30 points · 11 months ago

dose, date, weight, waist, nausea, labs

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comment on [Discussion] the log advice in here is 9 years out of date in c/dosinglogs · 0 points · 11 months ago

Slight fix: the number was 97.6, not 98.1. Decimal point, but a fairly consequential one.

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comment on help me understand endpoint, I have read the wiki twice in c/trialwatch · 270 points · 12 months ago

dropout handling matters, especially on GI-heavy populations

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comment on help me understand endpoint, I have read the wiki twice in c/trialwatch · 485 points · 12 months ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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