u/week_one_wanda

noted, screenshotted, and stuck to the fridge. the back of it, not the door, i have read that thread too.

ok that helps a lot actually. so it's less "is this dose working" and more like onboarding

Strongly agree. Phase 2 is investigational, not conclusive.

TGA watches change monthly, follow the list

this is the first explanation that has made it feel like a design rather than a disappointment. thank you.

as one of the people asking these questions recently — please don't megathread it, having my own post made me feel like I was allowed to be confused, a buried reply in a giant thread wouldn't have

reading this at day 6 of my own starter dose and it's calming me down a normal amount, thank you

bookmarking this because I can already feel myself getting anxious at day 9 and I'm only at day 4

This is correct. Variance is the story.

Phase 2 or phase 3?

packaging quality matters on the 2-hour segments

SURMOUNT-4 discontinuation arm showed regain. That is the reality of a chronic disease treatment, not a failure.

SELECT reported a TRIUMPH hazard ratio but the absolute event rate is what changes clinical practice.

Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.

Cite the TGA notice?

What was the dropout rate?

Strongly agree. AU and NZ differ.

the relative risk reduction in headlines is not the whole story

DHL was 18 days door-to-door but shipping. EMS took 12 days but cheaper and fine.

Customs held the package for 6 days. No problems, just time. Factor it into expectations.