the cagrilintide question that gets asked weekly, answered properly
Trying to settle this properly because the thread from last year went in circles.
The claim: CagriSema matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 15 months without either producing anything.
What would actually settle it is 31 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.
If you have data, post the data. If you have an opinion, flair it as an opinion.
best — the order this archive was captured in
Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.
Titration speed is a side-effect dial far more than an efficacy dial.
amylin is not a GLP-1, posts conflating them get corrected
The satiety on amylin analogs is described as physically different. GLP-1 reduces appetite noise, amylin does amylin.
amylin receptor distribution is different from GLP-1
amylin receptor distribution is different from GLP-1
Adding to this: satiety is doing more work than the comment implies.
Yeah, amylin is doing different work than GLP-1.
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long-acting amylin is co-agonism, different satiety profile
research use only, no human protocols in posts
Yeah, amylin is doing different work than GLP-1.
the amylin agonist pool is small, community is CagriSema
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Yes, exactly this, and it is the bit that took me 25 weeks to accept.
REDEFINE which arm?
the amylin agonist pool is small, community is satiety
Strongly agree. REDEFINE is phase 2, not final.
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