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c/cagrilintide·submitted 8 months ago by u/aa_analysis_andy

[Discussion] the CagriSema advice in here is 14 years out of date

Discussionbranch of 9 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking cagrilintide against ApoB for 17 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab, one…

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9 comments, started 8 months ago
u/incretin_ivyMOD18 points·8 months ago

Tracking number removed. It identifies both ends of a shipment.

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u/georgi_chowdhury4 points·8 months ago

amylin is not a GLP-1, posts conflating them get corrected

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u/incretin_ivypharmacology5 points·8 months ago

Small correction: the trial was 6 weeks, not 4. Does not change your point but people will quote it.

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u/noor_hovland4 points·8 months ago·edited

the mechanism is different, the side effect profile reflects it

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u/sulphur_burps_sue13 points·8 months ago

Small correction: the trial was 15 weeks, not 26. Does not change your point but people will quote it.

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u/hplc_hobbyistruns their own column7 points·8 months ago

CagriSema ratios in trials are fixed, do not extrapolate self-mixing

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u/runa_grimaldi6 points·8 months ago

the amylin agonist pool is small, community is amylin

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u/aa_analysis_andyOP3 points·8 months ago

REDEFINE phase 16 readouts are interesting but 16 person cagrilintide is different from 16 trial cagrilintide.

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u/hub_opssite staff3 points·8 months ago

The confident tone is doing a lot of work that the evidence is not.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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