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regain vs dose stretching — genuinely asking which matters more

Long Term Well Actually ×2 Slow Clap ×1

Genuinely asking, not being difficult.

Everyone in c/customs repeats that goal weight is important. I believe it, but I have never seen anyone show why, and when I search I get 15 threads of people agreeing with each other.

Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?

I am not trying to be the "source?" guy. I would just like a source.

2,124 up / 283 down88% upvoted53 commentsid o7wqie6 Apr 2025

53 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/yara_antonsen273 points·1 year ago

Half-life is about 168 hours, so steady state lands around week 15–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/adnan_sandvik220 points·1 year ago

Maintenance for 4 months now. 10mg every 40 days, weight 40±4kg. Found the rhythm.

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u/osman_ferrari176 points·1 year ago

Yeah, maintenance is the boring part and the important part.

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u/nadia_trevinoOP253 points·1 year ago

Yeah, maintenance is the boring part and the important part.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/noor_vermeulen57 points·1 year ago

the lowest dose you can stay on is not the lowest dose that works

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u/oskar_malinowski37 points·1 year ago·edited

Yeah, maintenance is the boring part and the important part.

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u/priya_weiss-25 points·1 year ago

Strongly agree. Lowest effective dose is a real discovery process.

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u/adnan_sandvik1 point·1 year ago

the 1.7mg dose works fine for 38 weeks of the month

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u/nadia_trevino93 points·1 year ago

regain after taper is expected, plan for it

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u/still_here_2026MOD45 points·1 year ago

Retitled to remove editorialising. Put the evidence in the body.

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u/oskar_malinowski21 points·1 year ago

the lowest dose you can stay on is not the lowest dose that works

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u/laila_almeida32 points·1 year ago

Not convinced. The evidence does not support that reading.

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u/column_dead_volume19 points·1 year ago

the 12.5mg dose works fine for 4 weeks of the month

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u/usp_appendixcompendial6 points·1 year ago

regain is not a moral failing

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u/mass_spec_maggieMS4 points·1 year ago

Did you stretch the dose interval?

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u/sofia_wikstrom13 points·1 year ago

the lowest dose you can stay on is not the lowest dose that works

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u/ewan_marchand11 points·1 year ago

the maintenance question changes at maintenance

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u/milos_vestergaard9 points·1 year ago·edited

the lowest dose you can stay on is not the lowest dose that works

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u/brigade_detector10 points·1 year ago

the regain question changes at maintenance

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u/omar_eriksen8 points·1 year ago

the regain question changes at maintenance

Yes, exactly this, and it is the bit that took me 95 weeks to accept.

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u/rohan_cardoso18 points·1 year ago

regain is not a moral failing

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u/throwaway_918223 points·1 year ago

Regain on a taper is expected. 21% back over 14 weeks, which matches the discontinuation data. Planned for it.

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u/ferritin_low13 points·1 year ago

Disagree. What you are describing is consistent with regain, not with what you concluded.

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u/incretin_ivypharmacology16 points·1 year ago
well that is my evening gone, thanks for the paper
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u/maintenance_mode_maxmaintenance5 points·1 year ago

nobody posts about this part and it is the longest part

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About c/maintenancephase

The part nobody posts about: what happens at goal weight. Finding a lowest effective dose, dose-interval stretching, regain risk data, muscle retention, the psychology of not having a number to chase, and staying on indefinitely versus tapering.

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c/maintenancephase rules
  1. State how long you have been at maintenance. "Maintenance" at week 30 is not maintenance.
  2. Regain is not a moral failing and posts implying it is get removed.
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