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c/orforglipron·submitted 1 year ago by u/marit_coelho

[Meta] proposal — a flair for orforglipron posts

Trial Databranch of 9 comments

Trying to settle this properly because the thread from last year went in circles. The claim: small molecule matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 13 months without either producing anything. What would actually settle it is 3 people measuring the…

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9 comments, started 1 year ago
u/phase_two_peteMOD290 points·1 year ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/neha_mwangi91 points·1 year ago·edited

Small correction: the trial was 22 weeks, not 7. Does not change your point but people will quote it.

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u/neha_krastev82 points·1 year ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/emil_marchand33 points·1 year ago

the ACHIEVE is whether this actually works long-term

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u/trialwatch_theotrial nerd0 points·1 year ago

Yeah, small molecule changes the whole game.

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[deleted]199 points·1 year ago

[deleted]

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u/flair_enthusiast290 points·1 year ago

the fatigue profile is speculative at this stage

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About c/orforglipron

The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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