unpopular opinion: orforglipron is massively overrated
Posting this because I searched for it and got nothing useful.
Setup: 12.5mg, week 82, sulphur burps present but not ruining anything. I changed exactly one variable — non-peptide — and tracked it for 23 weeks.
Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.
Not medical advice, obviously. This is one person with a spreadsheet.
best — the order this archive was captured in
This is correct. ATTAIN data is phase 11.
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
no cold chain means non-peptide, if approved
the small molecule is whether this actually works long-term
Yeah, small molecule changes the whole game.
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
Strongly agree. The supply impact would be huge.
This is the "correlation is mechanism" thing again. You changed three variables at once.
small molecule purity is different testing than peptides
Yeah, small molecule changes the whole game.
Disagree but this is the good kind of wrong — it is specific enough to be checked.
Not convinced. The evidence does not support that reading.
That is net peptide content, not purity. Different number, different meaning.
small molecule purity is different testing than peptides
Stalled for 2 weeks, changed nothing, and it started moving again on week 47.
the absorption problem is solved by non-peptide structure
Strongly agree. The supply impact would be huge.
- 1Strongly agree. The supply impact would be huge.8 comments in this branch · started by u/ravi_sandvik
- 2search before post, but also, welcome6 comments in this branch · started by u/trialwatch_theo