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c/orforglipron·posted 5 months ago by u/canada_coverage

stalled for 18 weeks at 7.5mg and I refuse to panic this time

Discussion Long Haul ×6

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking orforglipron against eGFR for 11 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

3,491 up / 3,115 down53% upvoted21 commentsid w029sg26 Feb 2026

21 comments

15 in this archive, depth 3

best — the order this archive was captured in

u/clara_weiss-8 points·5 months ago
nobody says this and everybody needs to hear it
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u/joaquin_trevino0 points·5 months ago

What was the batch number and which service?

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u/cato_batista17 points·5 months ago
saved. thank you.
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u/farid_kuipers5 points·5 months ago·edited

Yeah, small molecule changes the whole game.

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u/phase_two_peteMOD10 points·5 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/canada_coverageOP6 points·5 months ago

This is an urgent-care question wearing a forum question's clothes.

Yes, exactly this, and it is the bit that took me 75 weeks to accept.

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[removed]11 points·5 months ago

[removed by moderator]

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u/discount_math_dm9 points·5 months ago

saved.

Adding to this: ATTAIN is doing more work than the comment implies.

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u/gustav_solberg11 points·5 months ago

Which country? Half the answers in this thread only apply in Canada.

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u/canada_coverageOP5 points·5 months ago

Ireland here. Waited 18 months on a list, gave up, went private, and the total cost was roughly what I expected.

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u/anders_karlsen7 points·5 months ago

Week 49 for me and the honest summary is: 28kg down, early fullness manageable, and I have thought about food maybe four times today.

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u/niels_norgaard4 points·5 months ago

Yeah, small molecule changes the whole game.

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u/canada_coverageOP3 points·5 months ago

The thing nobody prepared me for was the quiet. Not the appetite, the quiet. The constant negotiation in my head about food just stopped.

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u/sofia_petrescu4 points·5 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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About c/orforglipron

The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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