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c/orforglipron·posted 3 months ago by u/tidy_vialdrawer_watch28

what would you tell week-1 you about non-peptide

Trial Data

Trying to settle this properly because the thread from last year went in circles.

The claim: small molecule matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 16 months without either producing anything.

What would actually settle it is 9 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

206 up / 63 down77% upvoted12 commentsid x40okc11 Apr 2026

12 comments

9 in this archive, depth 4

best — the order this archive was captured in

u/brigade_detector32 points·3 months ago

ATTAIN and ACHIEVE are phase 21 trials

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u/tidy_vialdrawer_watch28OP21 points·3 months ago

The thing nobody prepared me for was the quiet. Not the appetite, the quiet. The constant negotiation in my head about food just stopped.

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u/aksel_kjaer6 points·3 months ago

phase 5 data is interesting, phase 16 will tell the real story

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u/hedda_ekstrom17 points·3 months ago

Every time this gets posted it hits the front page and every time someone has to re-explain it.

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u/lucia_bruun4 points·3 months ago·edited

Yeah, small molecule changes the whole game.

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About c/orforglipron

The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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