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c/orforglipron·submitted 3 months ago by u/honest_syringe_maybe

ATTAIN — 3 things I got wrong before I got it right

Questionbranch of 11 comments

Trying to settle this properly because the thread from last year went in circles. The claim: small molecule matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 3 months without either producing anything. What would actually settle it is 31 people measuring the…

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11 comments, started 3 months ago
u/trialwatch_theoMOD219 points·3 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/lucia_bruun168 points·3 months ago

The injection-site soreness was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

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u/quiet_moderatormod81 points·3 months ago

Small correction: the trial was 3 weeks, not 3. Does not change your point but people will quote it.

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u/mateusz_mensah63 points·3 months ago

Yeah, small molecule changes the whole game.

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u/neha_rahimi32 points·3 months ago

the the food-noise thing profile is speculative at this stage

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u/honest_syringe_maybeOP-6 points·3 months ago

phase 8 data is interesting, phase 32 will tell the real story

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u/farid_kuipers34 points·3 months ago

oral non-peptide agonist is ACHIEVE, no food restrictions

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u/throwaway_wl2026102 points·3 months ago

This is an urgent-care question wearing a forum question's clothes.

Adding to this: ATTAIN is doing more work than the comment implies.

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u/honest_syringe_maybeOP41 points·3 months ago

The thing nobody prepared me for was the quiet. Not the appetite, the quiet. The constant negotiation in my head about food just stopped.

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u/marit_coelho177 points·3 months ago·edited

Respectfully this is a sample of one presented as a finding.

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About c/orforglipron

The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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