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c/reconstitution·posted 1 year ago by u/liv_nkemelu

genuine question about bacteriostatic water that I am slightly embarrassed to ask

Discussion Clean Column ×5 Sourced ×1

Quick one. Canada here.

reconstitution works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US.

Specifics: the route I used took 16 weeks and cost roughly what I expected. The admin was worse than the cost. The thing that would have saved me the most time was knowing which document to ask for at the start.

Happy to answer questions from anyone in the same jurisdiction.

2,625 up / 514 down84% upvoted36 commentsid 143u5014 Nov 2024

36 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/signe_grimaldi392 points·1 year ago

dosing errors come from people reconstituting two vials differently and forgetting which is which

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u/clara_weiss313 points·1 year ago

What was the vial size and how much bac water?

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u/rosa_mensah192 points·1 year ago

u-100 syringe, not u-40, or your math is off by factor of 11

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[removed]83 points·1 year ago

[removed by moderator]

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u/anya_antonsen204 points·1 year ago

Reconstituted at 3mL when I meant 9mL. Caught it because the units looked wrong. Write the concentration.

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u/arne_restrepo-5 points·1 year ago

I am going to push back on this slightly.

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u/julia_erdogan0 points·1 year ago

more water means more units for the same dose, which means finer resolution

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u/andres_sorensen1 point·1 year ago·edited

more water means more units for the same dose, which means finer resolution

Adding to this: reconstitution is doing more work than the comment implies.

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u/liv_nkemeluOP1 point·1 year ago

swirl, do not shake, or you are courting oxidation

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u/liv_nkemeluOP1 point·1 year ago

Reconstituted at 2mL when I meant 14mL. Caught it because the units looked wrong. Write the concentration.

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u/oskar_ibarra0 points·1 year ago

Not to be pedantic but bacteriostatic water and reconstitution are being used interchangeably and they are not interchangeable in real life.

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u/ilias_cabrera103 points·1 year ago

Half-life is about 168 hours, so steady state lands around week 16–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/saskia_rahimi38 points·1 year ago

10mg vial, 2mL water, concentration is 10/2 — write it on the vial afterwards

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u/bruno_dumitru26 points·1 year ago

the concentration on the vial in marker is the most important step

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u/swirl_dont_shakereconstitution14 points·1 year ago

Are you using a u-100 or u-40 syringe? That changes everything.

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u/runa_grimaldi66 points·1 year ago

dead space is real and the syringe matters

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u/sleep_apnea_sam19 points·1 year ago

Disagree. What you are describing is consistent with mg/mL, not with what you concluded.

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u/erez_perrin49 points·1 year ago

Slight fix: the number was 99.1, not 98.4. Decimal point, but a fairly consequential one.

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u/liv_nkemeluOP19 points·1 year ago

The single most useful thing I did was write the concentration on the vial. Stopped all the confusion after that.

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u/nabila_espinoza25 points·1 year ago

Slight fix: the number was 98.9, not 99.0. Decimal point, but a fairly consequential one.

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u/honest_syringe_maybe0 points·1 year ago

Show the arithmetic. Where did the units come from?

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u/india_generic_g1 point·1 year ago

u-100 syringe, not u-40, or your math is off by factor of 7

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u/lurker_for_years53 points·1 year ago

bacteriostatic and sterile water are not interchangeable, do not use them that way

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u/niels_roos31 points·1 year ago

Cosigning. The concentration on the vial in marker is load-bearing.

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u/honest_syringe_202525 points·1 year ago

Cored the stopper on my 18th draw because I kept using the same entry point. Rotate the puncture site.

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u/vial_math_veraMOD19 points·1 year ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/saskia_rahimi13 points·1 year ago

swirl, do not shake, or you are courting oxidation

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u/escrow_evangelist11 points·1 year ago

u-100 syringe, not u-40, or your math is off by factor of 21

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u/saskia_rahimi5 points·1 year ago

u-100 syringe, not u-40, or your math is off by factor of 24

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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