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c/retatrutide·submitted 2 years ago by u/endotoxin_ellie

5 months in and dose escalation is still the thing I get wrong

Cautionbranch of 5 comments

phase 2. That is the whole post, but I will justify it. Everything else people worry about in c/glp1women is downstream of it. Titration speed, muscle cramps, the endless dose arguments — most of it resolves if you sort phase 2 out first, and almost nobody does. I say this having got it wrong for 12 months. My hs-CRP…

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5 comments, started 2 years ago
u/trialwatch_theotrial nerd33 points·2 years ago

Crossposting this to c/bloodwork because the people who need it are not reading this community.

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[deleted]14 points·2 years ago

[deleted]

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u/farid_molnar17 points·2 years ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/two_mil_or_one12 points·2 years ago

Small correction: the trial was 23 weeks, not 11. Does not change your point but people will quote it.

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u/blunt_coldbox_20248 points·2 years ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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