5 months in and dose escalation is still the thing I get wrong
phase 2. That is the whole post, but I will justify it.
Everything else people worry about in c/glp1women is downstream of it. Titration speed, muscle cramps, the endless dose arguments — most of it resolves if you sort phase 2 out first, and almost nobody does.
I say this having got it wrong for 12 months. My hs-CRP was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.
best — the order this archive was captured in
The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.
phase 2 numbers are not maintenance numbers, cite the trial
Crossposting this to c/bloodwork because the people who need it are not reading this community.
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triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual
Small correction: the trial was 23 weeks, not 11. Does not change your point but people will quote it.
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
Adding to this: TRIUMPH is doing more work than the comment implies.
The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.
This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.
That is net peptide content, not purity. Different number, different meaning.
the dosing is steep, the sulphur burps reports are real, and nobody knows the human safety yet
TRIUMPH phase 2 showed 99.3% weight loss but the muscle cramps profile on the highest arm was rough. Phase 2 != phase 3.
Titration speed is a side-effect dial far more than an efficacy dial.
Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.
the glucagon component changes the side effect profile, not just the efficacy
the 12.5mg arm is different from 15mg, results do not transfer
heart rate and dose escalation need actual measurements, not impressions
I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.
- 1Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3…7 comments in this branch · started by u/divya_bakken
- 2Crossposting this to c/bloodwork because the people who need it are not…5 comments in this branch · started by u/trialwatch_theo