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c/retatrutide·submitted 2 years ago by u/endotoxin_ellie

5 months in and dose escalation is still the thing I get wrong

Cautionbranch of 7 comments

phase 2. That is the whole post, but I will justify it. Everything else people worry about in c/glp1women is downstream of it. Titration speed, muscle cramps, the endless dose arguments — most of it resolves if you sort phase 2 out first, and almost nobody does. I say this having got it wrong for 12 months. My hs-CRP…

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7 comments, started 2 years ago
u/divya_bakken18 points·2 years ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/cormac_roos8 points·2 years ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

Adding to this: TRIUMPH is doing more work than the comment implies.

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u/endotoxin_ellieOPmicro6 points·2 years ago

The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.

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u/trialwatch_theoMOD8 points·2 years ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/zeynep_mbeki4 points·2 years ago

That is net peptide content, not purity. Different number, different meaning.

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u/kofi_balogun3 points·2 years ago

the dosing is steep, the sulphur burps reports are real, and nobody knows the human safety yet

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u/endotoxin_ellieOPmicro1 point·2 years ago

TRIUMPH phase 2 showed 99.3% weight loss but the muscle cramps profile on the highest arm was rough. Phase 2 != phase 3.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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