u/endotoxin_ellie
LAL testing, sterility, and why "sterile filtered" is a sentence not a certificate.
long-standing contributor · micro · joined 28 Mar 2024
comment on reta phase 2 was -24.2% at 48 weeks and people quote it like it is a maintenance number in c/retatrutide · 41 points · 3 days ago
nobody should be giving this to anyone without extensive monitoring
comment on [Explainer] integration decisions change your number more than the sample does in c/hplc · 40 points · 8 days ago
The related substances profile is way more interesting than the main peak %. A 98% with 23 peaks is different from a 98% that is one 29% impurity.
comment on [Lane Report] Tianjin → Canada, 14 days, two of three vials cracked in c/intlshipping · 132 points · 18 days ago
I am going to push back on this slightly.
comment on small win: pentadecapeptide stopped being a problem at week 15 in c/bpc157 · 2 points · 20 days ago
[deleted]
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
comment on small win: pentadecapeptide stopped being a problem at week 15 in c/bpc157 · 31 points · 21 days ago
tendon and sequence literature in rodents is interesting
comment on MASH vs biopsy — genuinely asking which matters more in c/survodutide · 1 points · 25 days ago
glucagon injection is a different vector than GLP-1
comment on the contraception question that gets asked weekly, answered properly in c/glp1women · 1 points · 26 days ago
no cycle-tracking data with identifying details
comment on the phase 2 question that gets asked weekly, answered properly in c/retatrutide · 229 points · 1 months ago
This is correct. Triple agonism is genuinely different.
comment on [Discussion] glucagon is doing more work than we give it credit for in c/survodutide · 39 points · 1 months ago
Which trial arm?
comment on [Discussion] TRIUMPH is doing more work than we give it credit for in c/retatrutide · 1 points · 1 months ago
the dosing is steep, the fatigue reports are real, and nobody knows the human safety yet
comment on [Question] how do you actually verify glucagon in c/survodutide · 6 points · 1 months ago
glucagon injection is a different vector than GLP-1
comment on stalled for 9 weeks at 12.5mg and I refuse to panic this time in c/survodutide · 5 points · 1 months ago
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
comment on [Question] how do you actually verify dose escalation in c/retatrutide · 70 points · 1 months ago
TRIUMPH data is phase 2, not phase 3, smaller n and shorter
comment on the glucagon question that gets asked weekly, answered properly in c/retatrutide · 328 points · 1 months ago
Did you actually measure heart rate or is that a feeling?
comment on genuine question about biopsy that I am slightly embarrassed to ask in c/survodutide · 6 points · 1 months ago
the GLP-1/glucagon dual is hepatic fat, different from GIP/GLP-1
comment on what would you tell week-1 you about HPLC in c/hplc · 761 points · 2 months ago
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
comment on what would you tell week-1 you about HPLC in c/hplc · -18 points · 2 months ago
Strongly agree. Largest single impurity tells a different story than total purity.
comment on unpopular opinion: method development is massively overrated in c/hplc · 13 points · 2 months ago
Disagree but this is the good kind of wrong — it is specific enough to be checked.
comment on [Meta] the survodutide rule is doing its job and people should stop complaining in c/survodutide · 16 points · 2 months ago
Which trial arm?
comment on France: BPC-157, and what it actually costs here in c/bpc157 · 50 points · 3 months ago
regulatory status changed in 13 countries, check yours