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c/retatrutide·posted 3 days ago by u/clara_weiss

reta phase 2 was -24.2% at 48 weeks and people quote it like it is a maintenance number

Results The Quiet One ×8

Right, the triple agonist question again, but with numbers this time.

I have 24 data points over 24 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 59, not week 13. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

508 up / 128 down80% upvoted20 commentsid 1kcy6f26 Jul 2026

20 comments

17 in this archive, depth 3

best — the order this archive was captured in

u/ismael_eriksen85 points·2 days ago

The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.

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[removed]63 points·1 days ago

[removed by moderator]

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u/nikhil_asante100 points·2 days ago

nobody should be giving this to anyone without extensive monitoring

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u/ledger_modMOD49 points·1 days ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/clara_weiss58 points·1 days ago

What was the dosing schedule in that arm?

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u/clara_weissOP0 points·19 hr ago

The glucagon component does different things than dual agonism. The early fullness are not just amplified versions.

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u/endotoxin_elliemicro41 points·3 days ago

nobody should be giving this to anyone without extensive monitoring

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u/cagrilintide_enthusiast11 points·3 days ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

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u/nikhil_lindqvist28 points·3 days ago

I am going to push back on this slightly.

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u/trialwatch_theotrial nerd10 points·3 days ago

the dosing is steep, the early fullness reports are real, and nobody knows the human safety yet

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u/soren_nkemelu19 points·3 days ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/sofia_wikstrom21 points·2 days ago

Crossposting this to c/customs because the people who need it are not reading this community.

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u/quiet_moderatormod16 points·1 days ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/clara_weissOP7 points·1 days ago

Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.

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u/lurker_for_years18 points·3 days ago
this is why i still read c/newbiequestions
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u/hassan_nilsen6 points·2 days ago

the 1.7mg arm is different from 1.0mg, results do not transfer

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u/source_or_silence6 points·2 days ago

the dosing is steep, the fatigue reports are real, and nobody knows the human safety yet

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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c/retatrutide rules
  1. Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
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