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c/retatrutide·submitted 13 days ago by u/cormac_roos

came off reta after 14 weeks. here is the honest version.

Trial Databranch of 8 comments

phase 2. That is the whole post, but I will justify it. Everything else people worry about in c/glp1women is downstream of it. Titration speed, early fullness, the endless dose arguments — most of it resolves if you sort phase 2 out first, and almost nobody does. I say this having got it wrong for 22 months. My A1c…

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This branch

8 comments, started 13 days ago
u/lurker_for_years251 points·13 days ago

This is correct. Triple agonism is genuinely different.

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u/yusuf_ramos209 points·12 days ago

Not to be pedantic but retatrutide and glucagon are being used interchangeably and they are not interchangeable in real life.

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u/aa_analysis_andy283 points·12 days ago

Small correction: the trial was 15 weeks, not 5. Does not change your point but people will quote it.

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u/rui_only_ro74 points·12 days ago

What was the dosing schedule in that arm?

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u/kofi_balogun82 points·12 days ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/titration_marshalmod · c/semaglutide100 points·12 days ago

nobody should be giving this to anyone without extensive monitoring

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[removed]184 points·12 days ago

[removed by moderator]

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u/yannick_barros58 points·12 days ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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