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c/retatrutide·submitted 1 year ago by u/cold_chromatogram_only

anyone else notice retatrutide kicking in around week 49

Questionbranch of 8 comments

Confession thread, sort of. I went from 12.5mg to 5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 3 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have…

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8 comments, started 1 year ago
u/viktor_laurent-31 points·1 year ago

Every time this gets posted it hits the front page and every time someone has to re-explain it.

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u/kofi_balogun1 point·1 year ago

the weight curves are unusually steep, which makes predicting individual response harder

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u/reta_and_regret0 points·1 year ago

nobody should be giving this to anyone without extensive monitoring

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u/blunt_coldbox_20241 point·1 year ago

the weight curves are unusually steep, which makes predicting individual response harder

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u/signe_villalobos1 point·1 year ago

the weight curves are unusually steep, which makes predicting individual response harder

Adding to this: TRIUMPH is doing more work than the comment implies.

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u/nadia_trevino1 point·1 year ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/mod_cold_roommod · c/coldchain1 point·1 year ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/nikhil_lindqvist1 point·1 year ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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