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c/retatrutide·submitted 1 year ago by u/cold_chromatogram_only

anyone else notice retatrutide kicking in around week 49

Questionbranch of 12 comments

Confession thread, sort of. I went from 12.5mg to 5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 3 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have…

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12 comments, started 1 year ago
u/helga_vermeulen0 points·1 year ago

TRIUMPH phase 2 showed 99.0% weight loss but the constipation profile on the highest arm was rough. Phase 2 != phase 3.

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u/freya_baptista1 point·1 year ago

research use only, handling and analysis, not protocols

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u/trialwatch_theoMOD1 point·1 year ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/cold_chromatogram_onlyOP1 point·1 year ago

Flair changed to match the content.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/ewan_marchand1 point·1 year ago

the 12.5mg arm is different from 5mg, results do not transfer

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u/naomi_erdogan1 point·1 year ago

the dosing is steep, the sulphur burps reports are real, and nobody knows the human safety yet

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u/freya_baptista1 point·1 year ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/baseline_drifteranalytical1 point·1 year ago

triple agonism is dose escalation, do not generalise

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u/nordic_pricing1 point·1 year ago·edited

research use only, handling and analysis, not protocols

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u/lurker_for_years1 point·1 year ago

the dosing is steep, the sulphur burps reports are real, and nobody knows the human safety yet

Disagree on that part. 99.2% and 99.3% on the same vial is normal.

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[removed]1 point·1 year ago

[removed by moderator]

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u/liver_enzyme_liz0 points·1 year ago

the weight curves are unusually steep, which makes predicting individual response harder

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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