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c/retatrutide·posted 8 months ago by u/ferran_krastev

anyone else notice phase 2 kicking in around week 44

Caution Cold Box ×5 The Quiet One ×3

Trying to settle this properly because the thread from last year went in circles.

The claim: glucagon matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 22 months without either producing anything.

What would actually settle it is 5 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

1,203 up / 283 down81% upvoted51 commentsid jyf9g22 Nov 2025

51 comments

12 in this archive, depth 4

best — the order this archive was captured in

u/two_mil_or_one0 points·8 months ago

The glucagon component does different things than dual agonism. The early fullness are not just amplified versions.

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u/lurker_for_years104 points·8 months ago·edited

nobody should be giving this to anyone without extensive monitoring

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u/halima_mbeki58 points·8 months ago

TRIUMPH phase 2 showed 98.9% weight loss but the constipation profile on the highest arm was rough. Phase 2 != phase 3.

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u/nabila_bakken14 points·8 months ago

Not convinced. The evidence does not support that reading.

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u/elodie_grimaldi10 points·8 months ago

the 0.25mg arm is different from 0.5mg, results do not transfer

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u/zeynep_mbeki8 points·8 months ago

the 0.25mg arm is different from 0.5mg, results do not transfer

Disagree on that part. 96.8% and 96.2% on the same vial is normal.

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u/cormac_roos3 points·8 months ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/reflux_report1 point·8 months ago·edited

triple agonism is triple agonist, do not generalise

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u/matias_falk1 point·8 months ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/mateusz_mensah47 points·8 months ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/careful_gradient_again17 points·8 months ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

Yes, exactly this, and it is the bit that took me 59 weeks to accept.

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u/ledger_modmod · vetting32 points·8 months ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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