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c/retatrutide·submitted 8 months ago by u/ferran_krastev

anyone else notice phase 2 kicking in around week 44

Cautionbranch of 7 comments

Trying to settle this properly because the thread from last year went in circles. The claim: glucagon matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 22 months without either producing anything. What would actually settle it is 5 people measuring the same…

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7 comments, started 8 months ago
u/halima_mbeki58 points·8 months ago

TRIUMPH phase 2 showed 98.9% weight loss but the constipation profile on the highest arm was rough. Phase 2 != phase 3.

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u/nabila_bakken14 points·8 months ago

Not convinced. The evidence does not support that reading.

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u/elodie_grimaldi10 points·8 months ago

the 0.25mg arm is different from 0.5mg, results do not transfer

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u/zeynep_mbeki8 points·8 months ago

the 0.25mg arm is different from 0.5mg, results do not transfer

Disagree on that part. 96.8% and 96.2% on the same vial is normal.

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u/cormac_roos3 points·8 months ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/reflux_report1 point·8 months ago·edited

triple agonism is triple agonist, do not generalise

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u/matias_falk1 point·8 months ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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