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Single comment threadYou are looking at one branch of phase 2 vs triple agonist — genuinely asking which matters more — 27 comments in the full submission. View in context.
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c/retatrutide·submitted 2 months ago by u/rohan_cardoso

phase 2 vs triple agonist — genuinely asking which matters more

Trial Databranch of 7 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking retatrutide against triglycerides for 31 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one…

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7 comments, started 2 months ago
u/jarno_cabrera76 points·2 months ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/ewan_zielinski45 points·2 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/marit_laurent23 points·2 months ago

phase 2 numbers are not maintenance numbers, cite the trial

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u/ewan_zielinski16 points·2 months ago

triple agonism is phase 2, do not generalise

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u/renzo_yildiz0 points·2 months ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/aa_analysis_andy59 points·2 months ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/rui_only_ro35 points·2 months ago

Small correction: the trial was 17 weeks, not 38. Does not change your point but people will quote it.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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