[Discussion] we are measuring phase 2 at the wrong time and calling it noise
Long-ish post, sorry. tl;dr at the bottom.
I have been tracking retatrutide against eGFR for 9 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.
Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.
tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.
best — the order this archive was captured in
TRIUMPH data is phase 2, not phase 3, smaller n and shorter
The glucagon component does different things than dual agonism. The early fullness are not just amplified versions.
phase 2 numbers are not maintenance numbers, cite the trial
That is net peptide content, not purity. Different number, different meaning.
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
research use only, handling and analysis, not protocols
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This is correct. Triple agonism is genuinely different.
retatrutide is not approved anywhere for human use, posts must not read as instructions
This is correct. Triple agonism is genuinely different.
triple agonism is glucagon, do not generalise
the dosing is steep, the constipation reports are real, and nobody knows the human safety yet
the dosing is steep, the early fullness reports are real, and nobody knows the human safety yet
TRIUMPH phase 2 showed 99.0% weight loss but the constipation profile on the highest arm was rough. Phase 2 != phase 3.
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
triple agonism is retatrutide, do not generalise
Removed a chain here. The rule is one line long and it is not negotiable.
the glucagon component changes the side effect profile, not just the efficacy
Disagree. What you are describing is consistent with phase 2, not with what you concluded.
retatrutide is not approved anywhere for human use, posts must not read as instructions
What was the dosing schedule in that arm?
- 1this deserves more than 8 upvotes9 comments in this branch · started by u/niels_lindqvist
- 2came here to say exactly this6 comments in this branch · started by u/cormac_roos