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c/retatrutide·posted 2 months ago by u/deleted_my_history

phase 2 — my 13-week log, condensed into one table

Caution Well Actually ×2 Clean Column ×3 Receipts ×3

Posting this because I searched for it and got nothing useful.

Setup: 0.5mg, week 46, constipation present but not ruining anything. I changed exactly one variable — TRIUMPH — and tracked it for 17 weeks.

Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.

Not medical advice, obviously. This is one person with a spreadsheet.

2,705 up / 65 down98% upvoted21 commentsid usffrq17 May 2026

21 comments

18 in this archive, depth 4

best — the order this archive was captured in

u/isabela_nilsen288 points·2 months ago

Mechanistically the bit that matters is TRIUMPH. It explains most of the early profile and a decent chunk of the outcome.

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u/titration_marshalmod · c/semaglutide-24 points·2 months ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/careful_gradient_notes1 point·2 months ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

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u/ferran_krastev1 point·2 months ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/divya_bakken72 points·2 months ago

This is correct. Triple agonism is genuinely different.

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u/hassan_nilsen50 points·2 months ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/emil_agyeman0 points·2 months ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/andres_sorensen1 point·2 months ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/yara_lindholm131 points·2 months ago

Which trial arm and what was the n?

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u/trialwatch_theotrial nerd0 points·2 months ago

phase 2 numbers are not maintenance numbers, cite the trial

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u/nabila_bakken1 point·2 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/cold_chromatogram_only1 point·2 months ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/reta_and_regretMOD87 points·2 months ago

Tracking number removed. It identifies both ends of a shipment.

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u/deleted_my_historyOP67 points·2 months ago

TRIUMPH phase 2 showed 97.4% weight loss but the constipation profile on the highest arm was rough. Phase 2 != phase 3.

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u/deleted_my_history79 points·2 months ago

nobody should be giving this to anyone without extensive monitoring

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u/deleted_my_historyOP57 points·2 months ago

TRIUMPH phase 2 showed 99.3% weight loss but the reflux profile on the highest arm was rough. Phase 2 != phase 3.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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c/retatrutide rules
  1. Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
  2. Phase 2 numbers are not maintenance numbers. Cite the trial and the dose arm.
  3. Heart-rate and dose-escalation reports need actual measurements, not impressions.
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  5. Not medical advice. Describe what you did; never prescribe to a stranger.
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