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Single comment threadYou are looking at one branch of retatrutide vs TRIUMPH — genuinely asking which matters more — 65 comments in the full submission. View in context.
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c/retatrutide·submitted 2 months ago by u/emil_agyeman

retatrutide vs TRIUMPH — genuinely asking which matters more

Trial Databranch of 11 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking retatrutide against triglycerides for 35 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one…

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11 comments, started 2 months ago
u/honest_syringe33260 points·2 months ago
n=1 but same
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u/trialwatch_theotrial nerd201 points·2 months ago

the glucagon component changes the side effect profile, not just the efficacy

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u/nordic_pricing45 points·1 months ago

the glucagon component changes the side effect profile, not just the efficacy

Yes, exactly this, and it is the bit that took me 70 weeks to accept.

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[deleted]17 points·1 months ago

[deleted]

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u/lurker_for_years86 points·1 months ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/emil_agyemanOP60 points·1 months ago

Research use material only, no human-use approval anywhere. Posts must describe what happened, not instruct strangers.

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u/noor_ivaturi136 points·1 months ago

This is correct. Triple agonism is genuinely different.

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u/deleted_my_history90 points·1 months ago

Respectfully this is a sample of one presented as a finding.

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u/rohan_cardoso61 points·1 months ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/mod_cold_roommod · c/coldchain21 points·1 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/placebo_arm_pam17 points·1 months ago·edited

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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