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c/retatrutide·posted 2 months ago by u/emil_agyeman

retatrutide vs TRIUMPH — genuinely asking which matters more

Trial Data Clean Column ×5 Well Actually ×1 Receipts ×3

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking retatrutide against triglycerides for 35 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

4,333 up / 489 down90% upvoted65 commentsid vmb3co29 May 2026

65 comments

26 in this archive, depth 6

best — the order this archive was captured in

u/incretin_ivyMOD579 points·1 months ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/mateusz_mensah142 points·1 months ago

You have restated the marketing copy. What is the actual substance here.

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u/lane_watchermod · logistics39 points·1 months ago

the 12.5mg arm is different from 15mg, results do not transfer

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u/emil_agyeman24 points·1 months ago

the 12.5mg arm is different from 15mg, results do not transfer

Disagree on that part. 93.7% and 99.3% on the same vial is normal.

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u/elodie_grimaldi-21 points·1 months ago

Not to be pedantic but glucagon and triple agonist are being used interchangeably and they are not interchangeable in real life.

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u/dead_space_doug118 points·1 months ago·edited

the dosing is steep, the reflux reports are real, and nobody knows the human safety yet

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u/mod_cold_roommod · c/coldchain26 points·1 months ago

Respectfully this is a sample of one presented as a finding.

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u/dead_space_doug17 points·1 months ago

phase 2 numbers are not maintenance numbers, cite the trial

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u/nikhil_asante12 points·1 months ago

triple agonism is phase 2, do not generalise

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u/honest_syringe33260 points·2 months ago
n=1 but same
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u/trialwatch_theotrial nerd201 points·2 months ago

the glucagon component changes the side effect profile, not just the efficacy

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u/nordic_pricing45 points·1 months ago

the glucagon component changes the side effect profile, not just the efficacy

Yes, exactly this, and it is the bit that took me 70 weeks to accept.

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[deleted]17 points·1 months ago

[deleted]

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u/lurker_for_years86 points·1 months ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/emil_agyemanOP60 points·1 months ago

Research use material only, no human-use approval anywhere. Posts must describe what happened, not instruct strangers.

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u/noor_ivaturi136 points·1 months ago

This is correct. Triple agonism is genuinely different.

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u/deleted_my_history90 points·1 months ago

Respectfully this is a sample of one presented as a finding.

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u/rohan_cardoso61 points·1 months ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/mod_cold_roommod · c/coldchain21 points·1 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/placebo_arm_pam17 points·1 months ago·edited

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/fabio_lehtinen265 points·2 months ago·edited

triple agonism is glucagon, do not generalise

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u/marit_laurent87 points·2 months ago·edited

Not convinced. The evidence does not support that reading.

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u/andres_restrepo159 points·2 months ago

the 10mg arm is different from 7.5mg, results do not transfer

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u/dead_space_doug129 points·2 months ago·edited

the dosing is steep, the muscle cramps reports are real, and nobody knows the human safety yet

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u/nikhil_asante82 points·2 months ago

Did you actually measure heart rate or is that a feeling?

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u/jarno_cabrera131 points·1 months ago

the weight curves are unusually steep, which makes predicting individual response harder

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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