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c/survodutide·submitted 3 days ago by u/kasper_cabrera

[Paper] survodutide MASH data is the most interesting hepatic readout in the class

Paperbranch of 8 comments

Trying to settle this properly because the thread from last year went in circles. The claim: MASH matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 3 months without either producing anything. What would actually settle it is 9 people measuring the same thing…

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8 comments, started 2 days ago
u/julia_mensa29 points·2 days ago

MASH claims need the trial and the biopsy endpoint

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u/injection_site_iris23 points·1 days ago

Not convinced. The evidence does not support that reading.

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u/chidi_demir7 points·1 days ago

MASH claims need the trial and the biopsy endpoint

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u/kasper_cabreraOP4 points·1 days ago

I am going to push back on this slightly.

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u/heart_rate_bump5 points·1 days ago

the safety profile is not just tirzepatide amplified

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u/farid_kuipers6 points·1 days ago

Phase 12 or 17?

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u/whois_wanda3 points·1 days ago·edited

glucagon injection is a different vector than GLP-1

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u/annika_fonseca10 points·1 days ago

phase 20 data is interesting, phase 12 will be different

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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