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c/survodutide·submitted 1 year ago by u/britt_abubakar

[Results] 52 weeks, 25kg, and dual agonist was the hard part

Questionbranch of 10 comments

Trying to settle this properly because the thread from last year went in circles. The claim: MASH matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 24 months without either producing anything. What would actually settle it is 37 people measuring the same…

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10 comments, started 1 year ago
u/cormac_danquah52 points·1 year ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/customs_seizure_sid25 points·1 year ago

glucagon co-agonism has a different safety story

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u/vikram_mbeki36 points·1 year ago

rodent dual agonist is investigation only

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u/zeynep_ndiaye13 points·1 year ago

glucagon co-agonism has a different safety story

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u/sofia_ferreira8 points·1 year ago

Not to be pedantic but glucagon and MASH are being used interchangeably and they are not interchangeable in real life.

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u/hana_pereira3 points·1 year ago

the heart rate signal is real in the data

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u/throwaway_wl202618 points·1 year ago

Ireland here. Waited 14 months on a list, gave up, went private, and the total cost was roughly what I expected.

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u/lina_ndiaye25 points·1 year ago

Ireland here.

Disagree on that part. 93.7% and 99.3% on the same vial is normal.

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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