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c/survodutide·submitted 2 months ago by u/tomas_lokken

glucagon — 17 things I got wrong before I got it right

Cautionbranch of 8 comments

Quick one. Canada here. MASH works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US. Specifics: the route I used took 13 weeks and cost roughly what I expected. The admin was worse than the cost.…

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8 comments, started 2 months ago
u/peak_area_peteanalytical29 points·2 months ago

This is correct. Do not generalise from tirzepatide.

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u/zeynep_ndiaye20 points·2 months ago

the GLP-1/glucagon dual is hepatic fat, different from GIP/GLP-1

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u/britt_abubakar0 points·2 months ago

do not generalise from tirzepatide

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u/slow_logbook_notes301 point·2 months ago

phase 16 data is interesting, phase 4 will be different

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u/camila_marchand14 points·2 months ago

Which trial arm?

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u/runa_pires7 points·2 months ago

the safety profile is not just tirzepatide amplified

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u/kaia_cabrera5 points·2 months ago

Yeah, glucagon co-agonism is genuinely different.

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u/liv_vukovic4 points·2 months ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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