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c/survodutide·submitted 1 months ago by u/marisol_frisk

glucagon is the most under-discussed thing in c/scamalerts

Paperbranch of 6 comments

Something I noticed reading old threads that I have not seen said out loud. The advice on hepatic fat in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers…

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6 comments, started 1 months ago
u/elin_ferrari47 points·1 months ago

the MASH indication changes the risk calculus

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u/marisol_friskOP21 points·1 months ago

The confident tone is doing a lot of work that the evidence is not.

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u/border_paperwork11 points·1 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/marisol_friskOP18 points·1 months ago

MASH claims need the trial and the biopsy endpoint

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u/farid_kuipers10 points·1 months ago

the GLP-1/glucagon dual is hepatic fat, different from GIP/GLP-1

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u/titration_marshalmod · c/semaglutide13 points·1 months ago

do not generalise from tirzepatide

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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