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Single comment threadYou are looking at one branch of survodutide vs glucagon — genuinely asking which matters more — 58 comments in the full submission. View in context.
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c/survodutide·submitted 8 months ago by u/patient_labslip_log

survodutide vs glucagon — genuinely asking which matters more

Questionbranch of 13 comments

Confession thread, sort of. I went from 15mg to 7.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 13 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have early…

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13 comments, started 8 months ago
u/customs_seizure_sid30 points·8 months ago

Yeah, glucagon co-agonism is genuinely different.

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u/patient_labslip_log20 points·8 months ago

This is correct. Do not generalise from tirzepatide.

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u/draw_up_dizzy28 points·8 months ago

do not generalise from tirzepatide

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u/refund_ledger9 points·8 months ago

the MASH indication changes the risk calculus

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u/whois_wanda22 points·8 months ago·edited

You have restated the marketing copy. What is the actual substance here.

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u/lina_ndiaye6 points·8 months ago

the safety profile is not just tirzepatide amplified

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u/kaia_kuusela7 points·8 months ago·edited

The early fullness was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

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u/peak_area_peteanalytical3 points·8 months ago

do not generalise from tirzepatide

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u/peak_area_peteanalytical1 point·8 months ago

Strongly agree. The safety story is separate.

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u/crosspost_bot_no20 points·8 months ago

Yeah, glucagon co-agonism is genuinely different.

Yes, exactly this, and it is the bit that took me 77 weeks to accept.

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u/patient_labslip_logOP13 points·8 months ago

Small correction: the trial was 23 weeks, not 25. Does not change your point but people will quote it.

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u/camila_trevino4 points·8 months ago·edited

Which trial arm?

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u/valeria_karlsen9 points·8 months ago·edited

hepatic fat and survodutide are the story

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About c/survodutide

Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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