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Single comment threadYou are looking at one branch of my hs-CRP moved and I cannot work out whether Zepbound is why — 40 comments in the full submission. View in context.
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c/tirzepatide·submitted 1 year ago by u/rania_diallo

my hs-CRP moved and I cannot work out whether Zepbound is why

Side Effectsbranch of 11 comments

Quick one. Canada here. Zepbound works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US. Specifics: the route I used took 20 weeks and cost roughly what I expected. The admin was worse than the…

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11 comments, started 1 year ago
u/elin_ferrari1.2k points·1 year ago

Half-life is about 168 hours, so steady state lands around week 17–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/hub_opssite staff981 points·1 year ago

the 15mg is the top of the pen, not the required dose

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u/taper_off_tabitha-26 points·1 year ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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u/teodor_szabo1 point·1 year ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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[deleted]1 point·1 year ago

[deleted]

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u/ignacio_vanhecke1 point·1 year ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/certified_referenceQC1 point·1 year ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

Disagree on that part. 96.8% and 96.2% on the same vial is normal.

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u/swirl_dont_shakereconstitution0 points·1 year ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/incretin_ivypharmacology0 points·1 year ago

dual agonism is GIP, do not generalise from semaglutide

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u/coring_the_stopper1 point·1 year ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/georgi_chowdhury262 points·1 year ago

Half-life is about 168 hours, so steady state lands around week 17–5.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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